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Mesenchymal stem cells induce the expansion of regulatory T cells in abortion-prone mice.

AH Zarnani, SM Moazzeni
Journal PapersReproduction (Cambridge, England) , 2021 February 1, {Pages }

Abstract

Recurrent pregnancy loss (RPL) is one of the most common complications of early pregnancy associated in most cases with local or systemic immune abnormalities such as the diminished proportion of regulatory T cells (Tregs). Mesenchymal stem cells (MSCs) have been shown to modulate immune responses by de novo induction and expansion of Tregs. In this study, we analyzed the molecular and cellular mechanisms involved in Treg-associated pregnancy protection following MSCs administration in an abortion-prone mouse mating. In a case-control study, syngeneic abdominal fat-derived MSCs were administered intraperitoneally (ip) to the DBA/2-mated CBA/J female mice on day 4.5 of pregnancy. Abortion rate, Tregs proportion in spleen and inguinal lymph n

Mesenchymal stem cells induce the expansion of regulatory T cells in abortion-prone mice

Amir Salek Farrokhi, Amir-Hassan Zarnani, Seyed Mohammad Moazzeni
Journal PapersReproduction , Volume 1 , Issue aop, 2021 February 1, {Pages }

Abstract

Recurrent pregnancy loss (RPL) is one of the most common complications of early pregnancy associated in most cases with local or systemic immune abnormalities such as the diminished proportion of regulatory T cells (Tregs). Mesenchymal stem cells (MSCs) have been shown to modulate immune responses by de novo induction and expansion of Tregs. In this study, we analyzed the molecular and cellular mechanisms involved in Treg-associated pregnancy protection following MSCs administration in an abortion-prone mouse mating. In a case-control study, syngeneic abdominal fat-derived MSCs were administered intraperitoneally (i.p) to the DBA/2-mated CBA/J female mice on day 4.5 of pregnancy. Abortion rate, Tregs proportion in spleen and inguinal lymph

Optimized simple and affordable procedure for differentiation of monocyte-derived dendritic cells from LRF: An accessible and valid alternative biological source (vol 406 …

M Valizadeh, AA Pourfathollah, R Raoofian, A Homayoonfar, M Moazzeni
Journal Papers , , {Pages }

Abstract

Corrigendum to" Optimized simple and affordable procedure for differentiation of monocyte-derived dendritic cells from LRF: An accessible and valid alternative biological …

M Valizadeh, AA Pourfathollah, R Raoofian, A Homayoonfar, M Moazzeni
Journal Papers , , {Pages }

Abstract

Simultaneous transduction of dendritic cells with A20 and BTLA genes stimulates the development of stable and efficient tolerogenic dendritic cells and induces regulatory T cells

MR Javan, A Rahimpour, SM Moazzeni
Journal Papers , , {Pages }

Abstract

Optimized simple and affordable procedure for differentiation of monocyte-derived dendritic cells from LRF: An accessible and valid alternative biological source

M Valizadeh, AA Purfathollah, R Raoofian, A Homayoonfar, M Moazzeni
Journal Papers , , {Pages }

Abstract

Recombinant CD137‐Fc, its synthesis, and applications for improving the immune system functions, such as tumor immunotherapy and to reduce the inflammation due to the novel …

M Ajami, M Nazari, H Mahmoodzadeh, SM Moazzeni
Journal Papers , , {Pages }

Abstract

Mesenchymal stem cells induce expansion of regulatory T cells in abortion-prone mice

AS Farrokhi, AH Zarnani, SM Moazzeni
Journal Papers , , {Pages }

Abstract

Indirect Tumor Inhibitory Effects of MicroRNA-124 through Targeting EZH2 in The Multiple Myeloma Cell Line

Javid Sabour Takanlu, Arad Aghaie Fard, Saeed Mohammdi, Mohsen Nikbakht, Negin Afrang, Rezvan Tavakoli, Nooshin Tasharrofi, Fatemeh Kouhkan, Farnaz Razmkhah, Sorayya Ghasemi, Masoud Soleimani, Sedigheh Amini Kafi-abad, Arezou Mehrabi, Nafiseh Baheiraei, M
Journal PapersCell Journal (Yakhteh) , Volume 22 , Issue 1, 2020 March 1, {Pages }

Abstract

Objective: Multiple myeloma (MM) is an incurable plasma cell malignancy. Several genetic and epigenetic changes affect numerous critical genes expression status in this disorder. CDKN2A gene is expressed at low level in almost all cases with MM disease. The mechanism of this gene down-regulation has remained controversial. In the present study, we targeted EZH2 by microRNA-124 (miR-124) in L-363 cells and assessed following possible impact on CDKN2A gene expression and phenotypic changes.Materials and Methods: In this experimental study, growth inhibitory effects of miR-124 were measured by MTT assay in L-363 cell line. Likewise, cell cycle assay was measured by flowcytometery. The expression levels of EZH2 and CDKN2A were evaluated by real

Mesenchymal stem cells alter the frequency and cytokine profile of natural killer cells in abortion-prone mice.

Kahmini F Rezaei, Shahab Shahgaldi, Seyed Mohammad Moazzeni
Journal PapersJournal of cellular physiology , 2020 February 9, {Pages }

Abstract

Natural killer cells, which play a pivotal role in the establishment and maintenance of normal pregnancy, are the most abundant leukocytes at the fetomaternal interface that their subsets frequencies and cytokine profile are influential factors in the preservation of the decidual tolerogenic microenvironment. Any imbalance in NK cells' frequency and functions could be associated with pregnancy failure. Mesenchymal stem cells (MSCs) are shown to have immunomodulatory effects on NK cells and their cytokine profile. The purpose of this study is to evaluate the impact of MSCs therapy on the cytokine profiles and subpopulations of NK cells in a murine model of recurrent pregnancy loss. Adipose-derived MSCs were injected intraperitoneally to the

A Randomized, Triple-blind Placebo-controlled Trial to Determine the Effect of Saffron on the Serum Levels of MMP-9 and TIMP-1 in Patients with Multiple Sclerosis

Fatemeh Ghasemi Sakha, Amirreza Azimi Saeenb, Seyed Mohammad Moazzeni, Farnaz Etesamd, Gholamhassan Vaezi
Journal PapersIranian Journal of Allergy, Asthma and Immunology , 2020 April 20, {Pages 08-Jan }

Abstract

Matrix metalloproteinases-(MMP)-9 facilitates the migration of T-cells to central nervous system (CNS), while (Tissue Inhibitor of Metalloproteinases-1) TIMP-1 inhibits the function of MMP-9. This study aimed to determine the appropriate treatment option for multiple sclerosis (MS). Forty-three relapsing-remitting MS (RRMS) patients were randomly divided into two groups of 22 (group A, placebo) and 21 (group B, Saffron pill) individuals. Serum samples were collected from patients’ blood before using the Saffron pills/placebo pills and then after 12 months. The serum level of MMP-9 and its inhibitor, as well as TIMP-1, were measured by ELISA kits. Data were analysed using SPSS version 13. MMP-9 serum levels noticeably decreased in patients

Mesenchymal stem cells alter the frequency and cytokine profile of natural killer cells in abortion‐prone mice

Fatemeh Rezaei Kahmini, Shahab Shahgaldi, Seyed Mohammad Moazzeni
Journal PapersJournal of Cellular Physiology , 2020 February 9, {Pages }

Abstract

Natural killer cells, which play a pivotal role in the establishment and maintenance of normal pregnancy, are the most abundant leukocytes at the fetomaternal interface that their subsets frequencies and cytokine profile are influential factors in the preservation of the decidual tolerogenic microenvironment. Any imbalance in NK cells' frequency and functions could be associated with pregnancy failure. Mesenchymal stem cells (MSCs) are shown to have immunomodulatory effects on NK cells and their cytokine profile. The purpose of this study is to evaluate the impact of MSCs therapy on the cytokine profiles and subpopulations of NK cells in a murine model of recurrent pregnancy loss. Adipose‐derived MSCs were injected intraperitoneally to t

Uterine Dendritic Cells Modulation by Mesenchymal Stem Cells Provides A Protective Microenvironment at The Feto-Maternal Interface: Improved Pregnancy Outcome in Abortion-Prone?…

Maryam Eskandarian, Seyed Mohammad Moazzeni
Journal PapersCell Journal (Yakhteh) , Volume 12 , Issue 3, 2019 October 1, {Pages }

Abstract

Abstract Objective: Dendritic cells (DCs) as major regulators of the immune response in the decidua play a pivotal role in establishment and maintenance of pregnancy. Immunological disorders are considered to be the main causes of unexplained recurrent spontaneous abortions (RSAs). Recently, we reported that mesenchymal stem cells (MSCs) therapy could improve fetal survival and reduce the abortion rate in abortion-prone mice, although the precise mechanisms of this action are poorly understood. Since MSCs have been shown to exert immunomodulatory effects on the immune cells, especially DCs, this study was performed to investigate the capability of MSCs to modulate the frequency, maturation state, and phenotype of uterine DCs (uDCs) as a pot

Leukemia inhibitory factor (LIF) modulates the development of dendritic cells in a dual manner

Atefeh Yaftiyan, Maryam Eskandarian, Amir Hossein Jahangiri, Nazanin Atieh Kazemi Sefat, Seyed Mohammad Moazzeni
Journal PapersImmunopharmacology and immunotoxicology , 2019 May 29, {Pages 08-Jan }

Abstract

Objective: Dendritic cells (DCs) are professional antigen presenting cells majorly modulated by various environmental factors. Leukemia inhibitory factor (LIF) is a pleiotropic cytokine from interleukin-6 family. Previous studies demonstrate that LIF is associated with several tolerogenic events; yet the exact effect of this cytokine on the generation and function of DCs was not explicitly identified.Materials and methods: To clarify the role of LIF in DCs development, immature DCs were differentiated from mouse bone marrow (BM) in a GM-CSF and IL-4 containing medium with or without LIF. Afterwards, in maturation process, the differentiated DCs were exposed to TNF-α in the presence or absence of LIF.Results: Immature DCs differentiated in

Comparison of The Therapeutic Effect of Syngeneic, Allogeneic, and Xenogeneic Adipose Tissue-Derived Mesenchymal Stem Cells on Abortion Rates in A Mouse Model.

Fatemeh Rezaei Kahmini, Seyed Mohammad Moazzeni
Journal PapersCell Journal (Yakhteh) , Volume 12 , Issue 1, 2019 April 1, {Pages }

Abstract

ObjectiveMesenchymal stem cells (MSCs), due to their immunomodulatory functions, are an ideal candidate for the treatment of immune-related diseases. Recurrent spontaneous abortion (RSA) is one of the most common complications of pregnancy which in many cases is related to the immune system disorders. Our previous study has shown that the abortion rate was decreased following the syngeneic MSCs therapy in abortion-prone mice. In this study, the therapeutic effect of syngeneic, allogeneic, and xenogeneic MSCs was compared in a mouse model of RSA.Materials and MethodsIn this experimental study, MSCs were isolated from adipose tissue (ASCs) of CBA/J and BALB/c mice and human. After characterization, ASCs were injected (IP) at day 4 of gestatio

Uterine dendritic cells modulation by mesenchymal stem cells improved the outcome of pregnancy in abortion prone mice

M Eskandarian, SM Moazzeni
Conference PapersEUROPEAN JOURNAL OF IMMUNOLOGY , Volume 49 , 2019 October 1, {Pages 1612-1612 }

Abstract

Effects of opium (Taryak) detoxification on blood CD11c (+) myeloid and CD123 (+) plasmacytoid dendritic cells

A Ghazavi, SM Moazzeni, H Solhi, M Rafiei, S Fateh, G Mosayebi
Conference PapersEUROPEAN JOURNAL OF IMMUNOLOGY , Volume 49 , 2019 October 1, {Pages 503-503 }

Abstract

A review of accelerated wound healing approaches: biomaterial-assisted tissue remodeling

Shirin Nour, Nafiseh Baheiraei, Rana Imani, Mohammad Khodaei, Akram Alizadeh, Navid Rabiee, S Mohammad Moazzeni
Journal PapersJournal of Materials Science: Materials in Medicine , Volume 30 , Issue 10, 2019 October 1, {Pages 120 }

Abstract

Nowadays, due to a growing number of tissue injuries, in particular, skin wounds, induction and promotion of tissue healing responses can be considered as a crucial step towards a complete regeneration. Recently, biomaterial design has been oriented towards promoting a powerful, effective, and successful healing. Biomaterials with wound management abilities have been developed for different applications such as providing a native microenvironment and supportive matrices that induce the growth of tissue, creating physical obstacles against microbial contamination, and to be used as delivery systems for therapeutic reagents. Until now, numerous strategies aiming to accelerate the wound healing process have been utilized and stu

Bioactive materials: a comprehensive review on interactions with biological microenvironment based on the immune response

Shirin Nour, Nafiseh Baheiraei, Rana Imani, Navid Rabiee, Mohammad Khodaei, Akram Alizadeh, Seyed Mohammad Moazzeni
Journal PapersJournal of Bionic Engineering , Volume 16 , Issue 4, 2019 July 1, {Pages 563-581 }

Abstract

Application of “bioactive materials”, as a modified version of biomaterials, can optimize the response of the biological system due to their surface reactivity and formation of strong interactions with the adjacent tissue upon implantation. However, choosing an appropriate bioactive material that suits to the application and provides the desired mechanical, physical, chemical and biological functionality, as well as understanding the aspects of biological reaction to the biomaterial, in particular immune response, it plays a key role in successful integration of the implant. In this review, we will discuss different bioactive materials including bioactive ceramics, polymers and composites and their applications in drug de

New Insights Into Implementation of Mesenchymal Stem Cells in Cancer Therapy: Prospects for Anti-angiogenesis Treatment

Mohammad Reza Javan, Arezou Khosrojerdi, Seyed Mohammad Moazzeni
Journal PapersFrontiers in oncology , Volume 9 , 2019 January , {Pages 840 }

Abstract

Tumor microenvironment interacts with tumor cells, establishing an atmosphere to contribute or suppress the tumor development. Among the cells which play a role in the tumor microenvironment, mesenchymal stem cells (MSCs) have been demonstrated to possess the ability to orchestrate the fate of tumor cell, drawing the attentions to the field. MSCs have been considered as cells with double-bladed effects, implicating either tumorigenic or anti-tumor activity. On the other side, the promising potential of MSCs in treating human cancer cells has been observed from the clinical studies. Among the beneficial characteristics of MSCs are the natural tumor-trophic migration ability, providing facility for drug delivery and, therefore, targeted treat

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دروس نیمسال جاری

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