En
  • دکتری (1378)

    بیو شیمی

    دانشگاه تهران، ایران

  • کارشناسی‌ارشد (1368)

    بیو شیمی

    دانشگاه تربیت مدرس،

  • کارشناسی (1364)

    شیمی

    دانشگاه الزهرا / س /،

  • مطالعه مکانیزم عمل (ساختار-فعالیت) مواد موثره گیاهان دارویی در درمان دیابت، سرطان و ...
  • مطالعه مکانیزم اثر (ساختار-فعالیت) ملازم های شیمیایی (chemical chaperones) در درمان دیابت، سرطان و ...
  • مطالعه مسیرهای سیگنالینگ در بیماریهای مختلف (سرطان، دیابت و اختلالات عصبی) تحت اثر مولکولهای کوچک مثل مواد موثره زعفران و ملازمهای شیمیائی؛ با استفاده از روشهای بیوشیمیائی، بیوفیزیکی، بیولوژی مولکولی،
  • 2) بررسي رابطه ساختار- فعاليت DNA و پروتئين‌ها در هر دو شرايط برون‏تنی و درون‏تنی (in vivo و in vitro) در حضور ليگاندهاي مختلف
  • 3) استفاده از فناوری نانو در طراحي وساخت DNA بيوسنسور به منظور استفاده در تشخيص بيماري‌ها و مطالعه مکانیزم اثر داروها، و انتقال هدفمند داروها
  • اصلاح ساختار فعالیت بیوماکرومولکولها

داده ای یافت نشد

ارتباط

رزومه

L-lysine supplementation improved glycemic control, decreased protein glycation, and insulin resistance in type 2 diabetic patients

Hossein Mirmiranpour, S Zahra Bathaie, Shahnaz Khaghani, Manouchehr Nakhjavani, Abbas Kebriaeezadeh
Journal PapersInternational Journal of Diabetes in Developing Countries , 2021 February 17, {Pages 10-Jan }

Abstract

BackgroundLysine treatment decreased diabetic complications associated with type 2 diabetes in the rat models of diabetes and in vitro.

Predication of the Underlying Protective Effect of Saffron on Parkinson's Disease via Network Pharmacology and Molecular Docking

Junjie Gong, Zijin Xu, Shushu Hao, Boqian Chen, Shengcheng Zhuang, SZ Bathaie
Journal Papers , 2021 January 13, {Pages }

Abstract

BackgroundReports indicate that saffron originated from Iran then introduced into mainland China through the earlier established trans-Tibet trade routes in ancient China. Based to the theory of traditional Chinese medicine, saffron functions by promoting blood circulation and removing blood stasis, cooling blood and detoxi cation, as well as relieving depression for tranquilization. Modern medical research has demonstrated several properties of saffron including antitumor, antidepressant, enhancement of immunity, cardioprotection. Notably, recent studies introduce that saffron has a neuroprotective effect, speci cally in the treatment of Parkinson's disease in recent years. Nevertheless, the underlying molecular mechanism remains elusive s

The Structure of Spike Protein in SARS-Cov-2 and its Receptors on Host cell: Strategies for Drug Discovery Based on the Natural Products

Seyede Zahra Bathaie, Nassim Faridi, Abbasali Salarifar
Journal Papers , Volume 24 , Issue 1, 2021 March 10, {Pages 58-74 }

Abstract

The new Coronavirus, which was named SARS-CoV-2 is one of the members of the Coronavirus family, which induces Covid-19 or acute respiratory infection. This virus was firstly known in 2019 in Wuhan, China; and then, rapidly propagated around the world. In this review, we will present the structure and function of the Spike (S) protein in this virus and its receptors on the host cells. In addition to ACE2, which was initially identified as the cell surface receptor of this virus, it was observed that CD147 and GRP 78 also act as the receptors on host cells. Also, based on the mechanism of action, a brief introduction will present the drugs used to treat this Coronavirus. The drugs that target S protein, Proteinases; RNA-dependent RNA polymer

The in silico mechanism of hVKOR interaction with acetaminophen and its metabolite, as well as N-acetyl cysteine: caution on application in COVID-19 patients

S Ali Hashemi, Armita Kyani, S Zahra Bathaie
Journal PapersJournal of Biomolecular Structure and Dynamics , 2021 March 30, {Pages 12-Jan }

Abstract

Acetaminophen and N-acetyl cysteine (NAC) are being used as supportive care in patients suffering from coronavirus disease 2019 (COVID-19). The coagulopathy and cerebral hemorrhage have been recently reported in these patients. Prolonged acetaminophen use increases the international normalized ratio (INR) and the risk of bleeding among patients taking anti-coagulants. Inhibition of vitamin K epoxide reductase (VKOR) by acetaminophen and NAC in chronic applications has been reported, however, detailed knowledge of the molecular mechanism and binding sites are not clear. Herein, we built the homology model of human VKOR (hVKOR) using ITASSER server, confirmed, and applied it for docking analysis of its interaction with acetaminophen and its m

Possible role of WNT10B in increased proliferation and tubule formation of human umbilical vein endothelial cell cultures treated with hypoxic conditioned medium from human …

S Pourdashti, N Faridi, H Yaghooti, MT Jalali, A Soroush, SZ Bathaie
Journal Papers , , {Pages }

Abstract

The Role of BiP and the IRE1α–XBP1 Axis in Rhabdomyosarcoma Pathology

M Aghaei, A Nasimian, M Rahmati, P Kawalec, F Machaj, J Rosik, ...
Journal Papers , , {Pages }

Abstract

Cytosolic and mitochondrial ROS production resulted in apoptosis induction in breast cancer cells treated with Crocin: The role of FOXO3a, PTEN and AKT signaling

Ahmad Nasimian, Parvaneh Farzaneh, Fuyuhiko Tamanoi, S Zahra Bathaie
Journal PapersBiochemical Pharmacology , 2020 April 28, {Pages 113999 }

Abstract

Different groups have reported the Crocin anticancer activity. We previously showed Crocin-induced apoptosis in rat model of breast and gastric cancers, through the increased Bax/Bcl-2 ratio and caspases activity, as well as the cell cycle arrest in a p53-dependent manner. Since Crocin antioxidant activity has been shown under different conditions, it is interesting to elucidate its apoptotic mechanism. Here, we treated two breast cancer cell lines, MCF-7 and MDA-MB-231, with Crocin. MTT and ROS assays, cell cycle arrest, Bax/Bcl-2 ratio and caspase3 activity were determined. PARP cleavage and expression of some proteins were studied using Western blotting and immunofluorescence. The results indicated stepwise ROS generation in cytosol and

Saffron carotenoids change the superoxide dismutase activity in breast cancer: In vitro, in vivo and in silico studies

S Ali Hashemi, Masoumeh Karami, S Zahra Bathaie
Journal PapersInternational Journal of Biological Macromolecules , 2020 April 30, {Pages }

Abstract

Superoxide dismutase (SOD) is an important member of the antioxidant defense system and is proposed as a therapeutic agent against the ROS-mediated diseases, and a therapeutic target for cancer treatment. Saffron carotenoids, crocin (Cro) and crocetin (Crt), are antioxidants with anticancer activity. In the present study, we investigated the effects of Cro/Crt on the SOD activity in both in vivo and in vitro models of breast cancer. Both Cro and Crt showed strong radical scavenging activity and SOD inhibition in the MCF-7 breast cancer cell line. The UV–Vis, circular dichroism and fluorometry studies proposed the binding of both Cro and Crt with SOD; the ΔG? of binding at 310 K was −8.6 and −4.4 kcal/mol, respectively. The dockin

Aptamer-functionalized Fe3O4@ MOF nanocarrier for targeted drug delivery and fluorescence imaging of the triple-negative MDA-MB-231 breast cancer cells

Hamed Alijani, Abolhassan Noori, Nassim Faridi, S Zahra Bathaie, Mir F Mousavi
Journal PapersJournal of Solid State Chemistry , Volume 292 , 2020 December 1, {Pages 121680 }

Abstract

The development of efficient drug delivery and imaging approaches is of great importance for both diagnostic and therapeutic purposes. This is especially important for the triple-negative breast cancers for which chemotherapy is often the mainstay of treatment. Metal-organic frameworks (MOFs) have recently attracted tremendous attention as nanocarriers that can be loaded with a wide variety of therapeutic as well as bioimaging agents. Herein, the Fe3O4 core UiO-66-NH2 MOF shell nanostructures, Fe3O4@MOF, were loaded with the anticancer drug doxorubicin (DOX), and the loaded nanostructures were conjugated to highly fluorescent carbon dots (CDs) and then capped with the nucleolin-binding aptamer, AS1411. The Fe3O4@MOF-DOX-CDs-Apt nanocarriers

Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF‐κB, and MCP‐1 in patients with coronary artery disease: A …

N Abedimanesh, B Motlagh, S Abedimanesh, SZ Bathaie, A Separham, ...
Journal Papers , , {Pages }

Abstract

Prevention of α-crystallin glycation and aggregation using l-lysine results in the inhibition of in vitro catalase heat-induced-aggregation and suppression of cataract?…

Fereshteh Bahmani, S Zahra Bathaie, S Javid Aldavood, Arezou Ghahghaei
Journal PapersInternational journal of biological macromolecules , Volume 132 , 2019 July 1, {Pages 1200-1207 }

Abstract

The principle role of α-crystallin is chaperoning activity that protect s other proteins against different stresses. High glucose concentration induces the osmotic stress and results in biomacromolecules glycation, which is subsequently cause their conformational and functional changes. Here, the roles of l-lysine (Lys) on the prevention of α-crystallin glycation in both in vitro and in vivo conditions are investigated. The catalase (CAT) activity was considered as a marker of α-crystallin functionality in both conditions. Streptozotocin-induced diabetic rats were treated with 0.1% of the Lys in drinking water. The purified α-crystallin was also incubated with glucose, in the presence or absence of the Lys and its structure-function was

BT-474 Breast Cancer Cell Apoptosis Induced by Crocin, a Saffron Carotenoid

Nassim Faridi, Hamid Heidarzadeh, Mohammad Ali Mohagheghi, S Zahra Bathaie
Journal PapersBasic & Clinical Cancer Research , Volume 11 , Issue 1, 2019 January 2, {Pages }

Abstract

Background: Saffron carotenoids have been known as powerful phytochemicals in breast cancer treatment. The purpose of this study was to investigate the anti-cancer properties of an important saffron carotenoid, crocin, on BT-474 which is a known HER2+ breast cancer cell line. Methods: The effect of crocin on cell viability was investigated using MTT assay. Apoptosis induction was studied via flow cytometry and Western blotting of caspase-9 and cleaved caspase-9. Involvement of unfolded protein response (UPR) was also investigated via RT-PCR study of the XBP1 gene. Results: The results showed that crocin treatment decreases the viability of BT-474 cells and induces early and late apoptosis in these cells. The mechanism of crocin action was t

Role of Amino Acids on Prevention of Lens Proteins Nonenzymatic Glycation In Vitro, in Senile, and Diabetic Cataract

S Zahra Bathaie, Fereshteh Bahmani, Asghar Farajzadeh
Journal Papers , 2019 January 1, {Pages 245-270 }

Abstract

Glycation is the process by which reducing sugars bind to proteins, nonenzymatically. Then, a cascade of glycation reactions begin, which ultimately ends up producing various glycation products. A mechanism that is particularly important in diabetes and aging. Some chemicals, herbal, and chemical chaperones inhibit glycation process, and can be used to prevent or delay various diabetic complications, such as cataract. Free amino acids, such as Gly and Lys, are a class of chemical chaperones, preserve protein folding both in vivo and in vitro. They have shown varying degrees of antiglycating effect, decrease blood glucose, and delay diabetic complications. Here, we review the glycation process and the role of amino acids on inhibition of in

Comparison of the proteome patterns of adipose-derived stem cells with those treated with selegiline using a two dimensional gel electrophoresis analysis

M Mardani, T Tiraihi, SZ Bathaie, J Mirnajafi-Zadeh
Journal PapersBiotechnic & Histochemistry , 2019 October 5, {Pages 10-Jan }

Abstract

Adipose derived stem cells (ADSCs) are multipotent and can transdifferentiate into neural stem cells. We investigated the transdifferentiation of ADSCs to neural phenotype (NP) cells using selegiline and two-dimensional electrophoresis (2-DE). The perinephric and inguinal fat of rats was collected and used to isolate ADSCs that were characterized by immunophenotyping using flow cytometry. The ADSCs were differentiated into osteogenic and lipogenic cells. The NP cells were generated using 10−9 mM selegiline and characterized by immunocytochemical staining of nestin and neurofilament 68 (NF-68), and by qRT-PCR of nestin, neurod1 and NF68. Total protein of ADSCs and NP cells was extracted and their proteome patterns were examined using 2-DE.

Interaction of saffron carotenoids with catalase: in vitro, in vivo and molecular docking studies

S Ali Hashemi, S Zahra Bathaie, Mohammad-Ali Mohagheghi
Journal PapersJournal of Biomolecular Structure and Dynamics , 2019 September 27, {Pages 11-Jan }

Abstract

The effects of saffron carotenoids, crocetin (Crt) and crocin (Cro) on the structure, function and kinetics of catalase (CAT) were investigated. Both Crt and Cro quenched the fluorescence emission of CAT through the dynamic mechanism, but Crt (Ksv= 8.1 ? 104 mol−1) was more effective than Cro (Ksv= 0.6 ? 104 mol−1) at 300 ?K. The UV–vis and circular dichroism spectra showed conformational changes of CAT in the presence of both carotenoids, but with different degrees. Kinetic studies showed strong inhibition of CAT by Crt, while, different concentrations of Cro showed different effects. Our in vitro data showed that Crt treatment significantly (p = 0.002) reduced the CAT activity in MCF-7, up to 24 h. The in vivo resu

Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines

Seyed Ali Hashemi Hashemi, Seyedeh Zahra Bathaie, Mohammad Ali Mohagheghi
Journal PapersAvicenna Journal of Phytomedicine , 2019 December 18, {Pages }

Abstract

Objective: Inhibition of lipid metabolism in breast cancer has been suggested as an effective approach for cancer therapy. Saffron-derived crocetin (Crt) and crocin (Cro) with the known anticancer activity, have shown hypolipidemic effect in diabetes and atherosclerosis. Here, we investigated the effect of Crt/Cro on lipid content in breast cancer. Materials and Methods: A multi-model approach involving in vivo, in vitro and in silico studies was applied. The 4T1-induced breast cancer in mice was used to investigate the effect of Crt/Cro on cholesterol (Chl) and triglyceride (TG) levels in serum and tumor tissues. The Chl/TG levels were also assessed in the cytosol of MDA-MB-231 and MCF-7 breast cancer cell lines 6, 12 and 24 hr after Crt/C

Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF‐κB, and MCP‐1 in patients with coronary artery disease: A?…

Nasim Abedimanesh, Behrooz Motlagh, Saeed Abedimanesh, S Zahra Bathaie, Ahmad Separham, Alireza Ostadrahimi
Journal PapersPhytotherapy Research , 2019 December 3, {Pages }

Abstract

This trial evaluated the potential impacts of saffron aqueous extract (SAE) and its main carotenoid on some of the atherosclerosis‐related gene expression and serum levels of oxidized low‐density cholesterol (ox‐LDL) and Monocyte chemoattractant protein 1 (MCP‐1) in patients with coronary artery disease (CAD). Participants of this randomized controlled trial included 84 CAD patients who categorized into three groups: Group 1 received crocin (30 mg/day), Group 2 SAE (30 mg/day), and Group 3 placebo for 8 weeks. Gene expression of Sirtuin 1 (SIRT1), 5'‐adenosine monophosphate‐activated protein kinase (AMPK), Lectin‐like oxidized LDL receptor 1 (LOX1), nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB

L-lysine protects C2C12 myotubes and 3T3-L1 adipocytes against high glucose damages and stresses

S Mehdi Ebrahimi, S Zahra Bathaie, Nassim Faridi, Mohammad Taghikhani, Manouchehr Nakhjavani, Soghrat Faghihzadeh
Journal PapersPloS one , Volume 14 , Issue 12, 2019 January , {Pages }

Abstract

Hyperglycemia is a hallmark of diabetes, which is associated with protein glycation and misfolding, impaired cell metabolism and altered signaling pathways result in endoplasmic reticulum stress (ERS). We previously showed that L-lysine (Lys) inhibits the nonenzymatic glycation of proteins, and protects diabetic rats and type 2 diabetic patients against diabetic complications. Here, we studied some molecular aspects of the Lys protective role in high glucose (HG)-induced toxicity in C2C12 myotubes and 3T3-L1 adipocytes. C2C12 and 3T3-L1 cell lines were differentiated into myotubes and adipocytes, respectively. Then, they were incubated with normal or high glucose (HG) concentrations in the absence/presence of Lys (1 mM). To investigate the

The effect of crocetin supplementation on markers of atherogenic risk in patients with coronary artery disease: a pilot, randomized, double-blind, placebo-controlled clinical trial

Saeed Abedimanesh, S Zahra Bathaie, Alireza Ostadrahimi, Mohammad Asghari Jafarabadi, Mohammadreza Taban Sadeghi
Journal PapersFood & function , Volume 10 , Issue 11, 2019 January , {Pages 7461-7475 }

Abstract

Background and purpose: Molecular mechanisms of atherogenesis are considered to be emerging therapeutic targets for atherosclerosis prevention. Cell and animal studies have shown that crocetin can decelerate atherogenesis. However, the anti-atherogenic properties of crocetin in humans are still ambiguous. Methods and results: Fifty clinically diagnosed CAD patients were randomly divided into two parallel groups, crocetin and placebo, who received one capsule of crocetin (10 mg) and placebo per day, respectively, for two months. Serum circulating homocysteine (Hcy) [−1.09 (−1.64 to −0.54) μM, P = 0.001], heart-type fatty acid binding protein (h-FABP) [−2.07 (−2.72 to −1.43) ng mL−1, P = 0.001], intercellular adhesion molecule

Prevention of α-crystallin glycation and aggregation using l-lysine results in the inhibition of in vitro catalase heat-induced-aggregation and suppression of cataract …

F Bahmani, SZ Bathaie, SJ Aldavood, A Ghahghaei
Journal Papers , , {Pages }

Abstract

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دروس نیمسال جاری

  • دكتري
    بيوشيمي باليني 1 ( واحد)
    دانشکده علوم پزشکی، گروه بيو شيمي پزشكي
  • دكتري
    بيماري هاي متابوليك مادرزادي ( واحد)
  • كارشناسي ارشد
    بيوشيمي باليني ( واحد)

دروس نیمسال قبل

  • كارشناسي ارشد
    روشهاي آزمايشگاهي ، شناخت و كار با دستگاهها ( واحد)
    دانشکده علوم پزشکی، گروه بيو شيمي پزشكي
  • كارشناسي ارشد
    روشهاي آزمايشگاهي ، شناخت و كار با دستگاهها ( واحد)
  • كارشناسي ارشد
    متابوليسم مواد سه گانه و اختلالات ( واحد)
  • كارشناسي ارشد
    بيوشيمي پيشرفته بافتها ( واحد)
  • كارشناسي ارشد
    بيوانفورماتيك ( واحد)
  • كارشناسي ارشد
    بيوانفورماتيك ( واحد)
  • نسیم , فریدی
  • 1399
    محي الديني, متين
    تاثير ال-لايزين و لايسولين بر مسيرهاي اتوفاژي و UPR در عضله اسكلتي موش¬هاي مبتلا به ديابت.
  • 1395
    رخسارطلب اذر, شيرين
    بررسي اثر كروسين وكروستين بر مسير سيگنالينگ ERK/MAPK و Nrf2 / PI3K/AKT در رت مدل ديابت مغزي القا شده با استرپتوزوتوسين
  • 1397
    خادميان اقمشهدي, نرگس
  • مربي، استاديار، دانشيار و استاد، دانشگاه تربيت مدرس، تهران (از سال 1369 تا کنون)
  • فرصت مطالعاتی در دانشگاه UCLA، کالیفرنیا، آمریکا (از مهر 92 تا آخر شهریور 93)
  • استاد کالج علوم داروئی، دانشکاه بیوتکنولوژی جیجیانگ، چین (از 2017 تا 2020)
  • مربي مأمور به خدمت در دانشگاه شيراز 1371- 1369
  • عضو هیأت مدیره و مسئول کمیته علمی، انجمن بیوشیمی جمهوری اسلامی ایران (82 تا 91 و 95 تا کنون)
  • مدير گروه بيوشيمي باليني (81-83)
  • مسؤل دفتر امور هيأت علمي دانشكده علوم پزشكي (81-83) و (87 -89)
  • عضو شوراي نظارت و ارزيابي دانشكده علوم پزشكي (81 – 84 و 95 تا کنون)
  • عضو هیات موسس انجمن بیوشیمی فیزیک ایران
  • عضو قطب بیوترمودینامیک ایران
  • عضو شوراي نظارت و ارزيابي دانشكده علوم پزشكي (81 – 84 و 95 تا کنون)
  • عضو انجمن بيوشيمي جمهوري اسلامي ايران از 1370 تا کنون
  • استاد نمونه، دانشگاه تربیت مدرس 1396
  • پژوهشگر فرهیخته، وزارت بهداشت، 1395
  • استاد تلاشگر، دانشگاه تربیت مدرس، 1388.
  • برنده اولین دوره جایزه زنان در علم، وزارت علوم، 1396
  • بهترین سخنران در دومین کنگره بین‏المللی زعفران، 1384
  • پژوهشگر برتر دانشگاه تربيت مدرس، 1380
  • پژوهشگر برتر و اخذ پايه تشويقي، دانشگاه تربيت مدرس، 1385
  • پژوهشگر برتر، دانشگاه تربیت مدرس، 1387.
  • پژوهشگر فرهیخته، وزارت بهداشت، 1394
  • تقدیر به عنوان یکی از مجريان طرح ساخت داروي ضد ايدز (IMDO) 1385
  • جايزه جابربن حيان در دومين كنگره بيوشيمي، تهران، 1372
  • دانشجوي نمونه دانشگاه تهران و مركز تحقيقات بيوشيمي ـ بيوفيزيك، سه دوره متوالي (74 تا 76)
  • دریافت گرانت ICGEB براي شركت در كارگاه تئوري ساختار- عمل RNA، تريسته، ايتاليا، فرورين 1383
  • رتبه اول جشنواره رازی در بخش فنآوری های نوین، 1387.
  • رتبه پنجم جشنواره رازی 1389
  • سخنران برتر، پنجمین جشنواره زعفران طلای سرخ، قائن، آبان 1389
  • عضو انجمن بين‌المللي پروتئين (Protein Society) از 1999
  • عضو انجمن بين‌المللي فارماكولوژي (ASPET) از 2008
  • عضو انجمن بيوشيمي فيزيك ايران (هيأت مؤسس) از 1380
  • عضو انجمن پيشرفت علمي (AAAS) 2008 تا 2009
  • عضو انجمن نانوتكنولوژي از 1383

مهم

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